ARTICLE

SURGICAL TREATMENT OF PILOCYTIC ASTROCYTOMA IN ADULTS A STUDY OF 50 CASES AND LITERATURE REVIEW

  1. HOME
  2. ARTICLE

07 Pages : 33-38

http://dx.doi.org/10.31703/gpsr.2023(VIII-II).07      10.31703/gpsr.2023(VIII-II).07      Published : Jun 2023

Surgical Treatment of Pilocytic Astrocytoma in Adults: A Study of 50 Cases: and Literature Review

Abstract

    To study the effects of treatment in adults with pilocytic astrocytoma (PA), we conducted a survey including an examination of tiny case series and research in the literature. Our study comprised 50 patients who had PA surgery at MMC Mardan, Pakistan, between February 2018 and February 2023. Our main goal was overall survival (OS), whereas our secondary goals were morbidity, quality of life, and recurrence-free survival. The mean patient age was 27.7 years, with a range of 19–62 years, throughout our follow-up period of 38.3 months, which was between 0-85 months. The survival rate according to our findings was 77.2% (96% CI: 96.02-98.3%). Moreover, the adult recurrence-free survival rate after PA surgery was 95.01% (96.07% CI: 92.07-95.09%). Quality of life assessments after surgery was significantly better than before values [p 0.001]. Notably, the most frequent consequence in 7.08% of patients was postoperative seizures. These findings imply that adult patients with PA may benefit from surgical therapy in terms of quality of life and survival.

    Pilocytic Astrocytoma, Surgical, Retrospective Case Series

    (1) Naeem Ul Haq
    Associate Professor, Neurosurgery Unit, Mardan Medical Complex, Mardan, KP, Pakistan.
    (2) Syed Nasir Shah
    Registrar, Neurosurgery Unit, Mardan Medical Complex, Mardan, KP, Pakistan.
    (3) Sonia
    Post Graduate Resident, Radiology Unit, Mardan Medical Complex, Mardan, KP, Pakistan.
    (4) Sadaf Safeer
    Medical Officer, Neurosurgery Unit, Mardan Medical Complex, Mardan, KP, Pakistan.
    (5) Shoaib Ur Rehman
    Resident Neurosurgery, Mardan Medical Complex, Mardan, KP, Pakistan.
Fulltext PDF

References

  • Berger, M. S., Ghatan, S., Haglund, M. M., Dobbins, J., & Ojemann, G. A. (1993). Low-grade gliomas associated with intractable epilepsy: seizure outcome utilizing electrocorticography during tumor resection. Journal of Neurosurgery, 79(1), 62–69. https://doi.org/10.3171/jns.1993.79.1.0062
  • Bond, K. M., Hughes, J. D., Porter, A., Orina, J. N., Fang, S., & Parney, I. F. (2018). Adult Pilocytic Astrocytoma: An Institutional Series and Systematic Literature Review for Extent of Resection and Recurrence. World Neurosurgery, 110, 276–283. https://doi.org/10.1016/j.wneu.2017.11.102
  • Brown, P. D., Buckner, J. C., O’Fallon, J. R., Iturria, N. L., Brown, C. A., O’Neill, B. P., Scheithauer, B. W., Dinapoli, R. P., Arusell, R. M., Abrams, R. A., Curran, W. J., & Shaw, E. G. (2004). Adult patients with supratentorial pilocytic astrocytomas: a prospective multicenter clinical trial. International Journal of Radiation Oncology* Biology* Physics, 58(4), 1153–1160. https://doi.org/10.1016/j.ijrobp.2003.09.020
  • Chang, E. F., Potts, M. B., Keles, G. E., Lamborn, K. R., Chang, S. M., Barbaro, N. M., & Berger, M. S. (2008). Seizure characteristics and control following resection in 332 patients with low- grade gliomas. Journal of Neurosurgery, 108(2), 227–235. https://doi.org/10.3171/jns/2008/108/2/0227
  • de Oliveira Lima, G. L., & Duffau, H. (2015). Is there a risk of seizures in “preventive” awake surgery for incidental diffuse low-grade gliomas?. Journal of Neurosurgery, 122(6), 1397–1405. https://doi.org/10.3171/2014.9.jns141396
  • Kerkhof, M., & Vecht, C. J. (2013). Seizure characteristics and prognostic factors of gliomas. Epilepsia, 54, 12–17. https://doi.org/10.1111/epi.12437
  • Klein, M., Engelberts, N. H. J., van der Ploeg, H. M., Kasteleijn-Nolst Trenité, D. G. A., Aaronson, N. K., Taphoorn, M. J. B., Baaijen, H., Vandertop, W. P., Muller, M., Postma, T. J., & Heimans, J. J. (2003). Epilepsy in low-grade gliomas: The impact on cognitive function and quality of life. Annals of Neurology, 54(4), 514–520. https://doi.org/10.1002/ana.10712
  • Lombardi, D., Marsh, R., de Tribolet, N. (1997). Low Grade Glioma in Intractable Epilepsy: Lesionectomy versus Epilepsy Surgery. In: Ostertag, C.B., Thomas, D.G.T., Bosch, A.,
  • Lombardi, D., Marsh, R., de Tribolet, N. (1997). Low Grade Glioma in Intractable Epilepsy: Lesionectomy versus Epilepsy Surgery. In: Ostertag, C.B., Thomas, D.G.T., Bosch, A.,
  • Linderoth, B., Broggi, G. (eds) Advances in Stereotactic and Functional Neurosurgery 12. Acta Neurochirurgica Supplements, vol 68. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6513-3_13
  • Luzzi, S., Elia, A., Del Maestro, M., Elbabaa, S. K., Carnevale, S., Guerrini, F., Caulo, M., Morbini, P., & Galzio, R. (2019). Dysembryoplastic Neuroepithelial Tumors: What You Need to Know. World Neurosurgery, 127, 255–265. https://doi.org/10.1016/j.wneu.2019.04.056
  • Mansur, D. B., Rubin, J. B., Kidd, E. A., King, A. A., Hollander, A. S., Smyth, M. D., Limbrick, D. D., Park, T. S., & Leonard, J. R. (2011). Radiation Therapy for Pilocytic Astrocytomas of Childhood. International Journal of Radiation Oncology*Biology*Physics, 79(3), 829–834. https://doi.org/10.1016/j.ijrobp.2009.11.015
  • Ng, S., Herbet, G., Moritz-Gasser, S., & Duffau, H. (2019). Return to Work Following Surgery for Incidental Diffuse Low-Grade Glioma: A Prospective Series With 74 Patients. Neurosurgery, 87(4), 720–729. https://doi.org/10.1093/neuros/nyz513
  • Park, Y. M., Kim, D., Eom, J., Ahn, S. S., Moon, J. H., Kim, E. H., Kang, S. M., Chang, J. H., Kim, H., & Lee, S. H. (2021). A diagnostic tree for differentiation of adult pilocytic astrocytomas from high-grade gliomas. European Journal of Radiology, 143, 109946–109946. https://doi.org/10.1016/j.ejrad.2021.109946
  • Ryu, H.-H., Jung, T.-Y., Lee, G., Herschorn, S., Jung, S.-H., Jung, S., & Hee Jo Baek. (2015). Differences in the clinical courses of pediatric and adult pilocytic astrocytomas with progression: a single-institution study. Child’s Nervous System, 31(11), 2063–2069. https://doi.org/10.1007/s00381-015-2887-z
  • Santos-Pinheiro, F., Park, M., Liu, D., Kwong, L. N., Cruz, S., Levine, N. B., O’Brien, B. J., & Chen, M. (2019). Seizure burden pre- and postresection of low-grade gliomas as a predictor of tumor progression in low-grade gliomas. Neuro-Oncology Practice, 6(3), 209– 217. https://doi.org/10.1093/nop/npy022
  • aphoorn, M. J. B., Sizoo, E. M., & Bottomley, A. (2010). Review on Quality of Life Issues in Patients with Primary Brain Tumors. The Oncologist, 15(6), 618–626. https://doi.org/10.1634/theoncologist.2009-0291
  • Theeler, B., Ellezam, B., Sadighi, Z. S., Mehta, V., Tran, M. D., Adesina, A. M., Bruner, J. M., & Puduvalli, V. K. (2014). Adult pilocytic astrocytomas: clinical features and molecular analysis. Neuro-Oncology, 16(6), 841–847. https://doi.org/10.1093/neuonc/not246

Cite this article

APA

    APA : Haq, N. U., Shah, S. N., & Sonia. (2023). Surgical Treatment of Pilocytic Astrocytoma in Adults: A Study of 50 Cases: and Literature Review. Global Pharmaceutical Sciences Review, VIII(II), 33-38. https://doi.org/10.31703/gpsr.2023(VIII-II).07

CHICAGO

    CHICAGO : Haq, Naeem Ul, Syed Nasir Shah, and Sonia. 2023. "Surgical Treatment of Pilocytic Astrocytoma in Adults: A Study of 50 Cases: and Literature Review." Global Pharmaceutical Sciences Review, VIII (II): 33-38 doi: 10.31703/gpsr.2023(VIII-II).07

HARVARD

    HARVARD : HAQ, N. U., SHAH, S. N. & SONIA. 2023. Surgical Treatment of Pilocytic Astrocytoma in Adults: A Study of 50 Cases: and Literature Review. Global Pharmaceutical Sciences Review, VIII, 33-38.

MHRA

    MHRA : Haq, Naeem Ul, Syed Nasir Shah, and Sonia. 2023. "Surgical Treatment of Pilocytic Astrocytoma in Adults: A Study of 50 Cases: and Literature Review." Global Pharmaceutical Sciences Review, VIII: 33-38

MLA

    MLA : Haq, Naeem Ul, Syed Nasir Shah, and Sonia. "Surgical Treatment of Pilocytic Astrocytoma in Adults: A Study of 50 Cases: and Literature Review." Global Pharmaceutical Sciences Review, VIII.II (2023): 33-38 Print.

OXFORD

    OXFORD : Haq, Naeem Ul, Shah, Syed Nasir, and Sonia, (2023), "Surgical Treatment of Pilocytic Astrocytoma in Adults: A Study of 50 Cases: and Literature Review", Global Pharmaceutical Sciences Review, VIII (II), 33-38

TURABIAN

    TURABIAN : Haq, Naeem Ul, Syed Nasir Shah, and Sonia. "Surgical Treatment of Pilocytic Astrocytoma in Adults: A Study of 50 Cases: and Literature Review." Global Pharmaceutical Sciences Review VIII, no. II (2023): 33-38. https://doi.org/10.31703/gpsr.2023(VIII-II).07