01 Pages : 1-5
http://dx.doi.org/10.31703/gpsr.2016(I-I).01 10.31703/gpsr.2016(I-I).01 Published : Dec 2016Novel Crosslinking Methods to Design Hydrogels
Hydrogels are presently under consideration as matrices for the controlled bioactive molecules delivery particularly proteins and for living cells encapsulation. For these applications, gels must undergo degradation under physiological conditions. This overview summarized and discussed the various physical and chemical crosslinking methods to design hydrogels that are biodegradable. Highly versatile method to prepare hydrogels with good mechanical stability is chemical crosslinking. However, the crosslinker employed can give undesirable reactions with the bioactive substances present in the hydrogel matrix and are often toxic. So, it required to be removed from the gels before application. Physically crosslinked gels can be developed to overcome these adverse effects. Distortion due to variations in environmental conditions like presence of solute particles, ionic strength, pH, temperature and stress are the major disadvantages of reversible gels
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Smoking, Addiction, Bahawalpur community
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(1) Hina Shoukat
Faculty of Pharmacy & Alternative medicine, The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan.
(2) Fahad Pervaiz
Assistant Professor, Faculty of Pharmacy & Alternative medicine, The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan.
(3) Sobia Noreen
Faculty of Pharmacy & Alternative medicine, The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan.
- Ahmed, E. M. (2015). Hydrogel: preparation, characterization, and applications: a review. J Adv Res 6:105-12.
- Gupta, P., Vermani, K., & Garg, S. (2002). Hydrogels: from controlled release to pH- responsive drug delivery. Drug Discov Today 7:569-579.
- Hennink, W. E., & van Nostrum, C. F. (2012). Novel crosslinking methods to design hydrogels. Adv Drug Deliv Rev 64:223-236
- Ganji, F., & VASHEGHANI, F. E. (2009). Hydrogels in controlled drug delivery systems. Iran Polym J 18:63-88.
- Gothoskar, A. V., Joshi, A. M., & Joshi, N. H. (2004). Pulsatile drug delivery systems: a review. J Drug Deliv Sci Technol 4:1-11
- Peppas, N., Bures, P., Leobandung, W., & Ichikawa, H. (2000). Hydrogels in pharmaceutical formulations. Eur J Pharm Biopharm 50:27-46
- Lee, S. C., Kwon, I. K., & Park, K. (2013). Hydrogels for delivery of bioactive agents: a historical perspective. Adv Drug Deliv Rev 65:17-20
- Wichterle, O., & Lim, D. (1960). Hydrophilic gels for biological use. Nature 185:117-118
- Maitra, J., & Shukla, V. K. (2014). Cross-linking in hydrogels-a review. Am J Polym Sci 4:25-31
- Tillet, G., Boutevin, B., & Ameduri, B. (2011). Chemical reactions of polymer crosslinking and post-crosslinking at room and medium temperature. Prog. Polym. Sci 36:191-217
- Deligkaris, K., Tadele, T. S., Olthuis, W., & van den, & Berg, A. (2010). Hydrogel-based devices for biomedical applications. Sens. Actuators B Chem 147:765-774
- Hoffman, A. S. (2012). Hydrogels for biomedical applications. Adv Drug Deliv Rev 64:18-23
- Gulrez, S. K., Al-Assaf, S., & Phillips, G. O. (2011). Hydrogels: methods of preparation, characterisation and applications. In: Angelo Carpi (ed) Progress in Molecular and Environmental Bioengineering, 1st edn. IntechOpen, London, pp 117-150
- Chen, Y. L. (2008). Preparation and characterization of Water-soluble chitosan gel for skin Hydration. Mph thesis. Univ Sains Malaysia 1- 181.
- Watanabe, T., Ohtsuka, A., Murase, N., Barth, P., & Gersonde, K. (1996). NMR studies on water and polymer diffusion in dextran gels. Influence of potassium ions on microstructure formation and gelation mechanism. Magn Reson Med 35:697-705
- Zhang, J., Wang, N., Liu, W., Zhao, X., & Lu, W. (2013.) Intermolecular hydrogen bonding strategy to fabricate mechanically strong hydrogels with high elasticity and fatigue resistance. Soft Matter 9:6331-6337
- Eagland, D., Crowther, N., & Butler, C. (1994). Complexation between polyoxyethylene and polymethacrylic acid'the importance of the molar mass of polyoxyethylene. Eur Polym J 30:767-773
- Bates, F. S., & Fredrickson, G. H. (1990). Block copolymer thermodynamics: theory and experiment. Annu Rev Phys Chem. 41:525-557
- McGrath, J. (1981). Block and graft copolymers. In State-of-the-Art Symposium: Polymer Chemistry; Atlanta ACS meeting. J Chem Ed. 58: 914- 921.
- Kumar, A. (2016). Supermacroporous Cryogels: Biomedical and biotechnological applications. CRC Press. Taylor & Francis Group, Boca Raton
- Wang, M., Fang, Y., & Hu, D. (2001). Preparation and properties of chitosan-poly (N- isopropylacrylamide) full-IPN hydrogels. React Funct Polym 48:215-221
- Dai, W., & Barbari, T. (1999). Hydrogel membranes with mesh size asymmetry based on the gradient crosslinking of poly (vinyl alcohol). J Membr Sci 156:67-79
- Dayer, P., Collart, L., & Desmeules, J. (1994). The pharmacology of tramadol. Drugs 47:3-7.
- Sperinde, J. J., & Griffith, L. G. (1997). Synthesis and characterization of enzymatically-cross-linked poly (ethylene glycol) hydrogels. Macromolecules 30:5255-5264.
Cite this article
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APA : Shoukat, H., Pervaiz, F., & Noreen, S. (2016). Novel Crosslinking Methods to Design Hydrogels. Global Pharmaceutical Sciences Review, I(I), 1-5. https://doi.org/10.31703/gpsr.2016(I-I).01
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CHICAGO : Shoukat, Hina, Fahad Pervaiz, and Sobia Noreen. 2016. "Novel Crosslinking Methods to Design Hydrogels." Global Pharmaceutical Sciences Review, I (I): 1-5 doi: 10.31703/gpsr.2016(I-I).01
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HARVARD : SHOUKAT, H., PERVAIZ, F. & NOREEN, S. 2016. Novel Crosslinking Methods to Design Hydrogels. Global Pharmaceutical Sciences Review, I, 1-5.
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MHRA : Shoukat, Hina, Fahad Pervaiz, and Sobia Noreen. 2016. "Novel Crosslinking Methods to Design Hydrogels." Global Pharmaceutical Sciences Review, I: 1-5
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MLA : Shoukat, Hina, Fahad Pervaiz, and Sobia Noreen. "Novel Crosslinking Methods to Design Hydrogels." Global Pharmaceutical Sciences Review, I.I (2016): 1-5 Print.
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OXFORD : Shoukat, Hina, Pervaiz, Fahad, and Noreen, Sobia (2016), "Novel Crosslinking Methods to Design Hydrogels", Global Pharmaceutical Sciences Review, I (I), 1-5
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TURABIAN : Shoukat, Hina, Fahad Pervaiz, and Sobia Noreen. "Novel Crosslinking Methods to Design Hydrogels." Global Pharmaceutical Sciences Review I, no. I (2016): 1-5. https://doi.org/10.31703/gpsr.2016(I-I).01