ARTICLE

SYNTHESIS AND INVITRO CHARACTERIZATION OF CELECOXIB EMULGEL

03 Pages : 17-28

http://dx.doi.org/10.31703/gpsr.2016(I-I).03      10.31703/gpsr.2016(I-I).03      Published : Dec 2016

Synthesis and In-vitro Characterization of Celecoxib Emulgel

    The study was aimed at developing a topical preparation of Celecoxib, a COX inhibitor available in oral dosage form only, for localized and systemic effects. Initially, celecoxib containing microemulsion was developed using liquid paraffin, tween 20, water, methyl paraben, propyl paraben, menthol and clove oil. These components were incorporated into Carbopol 934 gel, with varying ratio to achieve stable emulgel formulation. The emulgel appeared as smooth white homogenized formulation having pH 6.6-6.8. The rheological properties showed pseudo plastic nature with yield stress. The spreadability and extrudability showed sufficient consistency for ease of processing, filling and application. Microbial assay showed no contamination to ensure the stability of formulation upon storage. Ex-vivo bio-adhesive strength and skin irritation test showed no irritation on rat skin. All these parameters suggested that emulgel can be explored and developed as an effective alternative formulation for the local and systemic application of celecoxib. various body tissues, connected by blood circulatory system. Another name for non-compartmental analysis is model-independent approach that means it does not require any compartment model.

    Emulgel, Celecoxib, Carbopol 934, topical
    (1) Zahrah Hasan
    M.Phil. Scholar, Riphah Institute of Pharmaceutical Sciences, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Lahore, Punjab, Pakistan.
    (2) Maryam Anwar
    Ph.D. scholar, Saulat Institute of Pharmaceutical Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
    (3) Muhammad Farhan Sohail
    Associate Professor, Riphah Institute of Pharmaceutical Sciences, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Raiwind Road, Lahore, Punjab, Pakistan.
    (4) Tanveer Ahmed Khan
    Ph.D. scholar, Saulat institute Of Pharmaceutical Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
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Cite this article

    APA : Hasan, Z., Anwar, M., & Sohail, M. F. (2016). Synthesis and In-vitro Characterization of Celecoxib Emulgel. Global Pharmaceutical Sciences Review, I(I), 17-28. https://doi.org/10.31703/gpsr.2016(I-I).03
    CHICAGO : Hasan, Zahrah, Maryam Anwar, and Muhammad Farhan Sohail. 2016. "Synthesis and In-vitro Characterization of Celecoxib Emulgel." Global Pharmaceutical Sciences Review, I (I): 17-28 doi: 10.31703/gpsr.2016(I-I).03
    HARVARD : HASAN, Z., ANWAR, M. & SOHAIL, M. F. 2016. Synthesis and In-vitro Characterization of Celecoxib Emulgel. Global Pharmaceutical Sciences Review, I, 17-28.
    MHRA : Hasan, Zahrah, Maryam Anwar, and Muhammad Farhan Sohail. 2016. "Synthesis and In-vitro Characterization of Celecoxib Emulgel." Global Pharmaceutical Sciences Review, I: 17-28
    MLA : Hasan, Zahrah, Maryam Anwar, and Muhammad Farhan Sohail. "Synthesis and In-vitro Characterization of Celecoxib Emulgel." Global Pharmaceutical Sciences Review, I.I (2016): 17-28 Print.
    OXFORD : Hasan, Zahrah, Anwar, Maryam, and Sohail, Muhammad Farhan (2016), "Synthesis and In-vitro Characterization of Celecoxib Emulgel", Global Pharmaceutical Sciences Review, I (I), 17-28
    TURABIAN : Hasan, Zahrah, Maryam Anwar, and Muhammad Farhan Sohail. "Synthesis and In-vitro Characterization of Celecoxib Emulgel." Global Pharmaceutical Sciences Review I, no. I (2016): 17-28. https://doi.org/10.31703/gpsr.2016(I-I).03