ARTICLE

SPINAL TUMORS CLINICAL SPECTRUM AND SURGICAL OUTCOMES INSTITUTIONAL EXPERIENCE FROM A SINGLE CENTER

02 Pages : 6-11

http://dx.doi.org/10.31703/gpsr.2023(VIII-II).02      10.31703/gpsr.2023(VIII-II).02      Published : Jun 2023

Spinal Tumors' Clinical Spectrum and Surgical Outcomes: Institutional Experience from a Single Center

    The goal of this research was to assess the outcomes of spinal tumour surgery and the broad range of patient clinical experiences. Retrospective analysis of data was performed on all patients who had spinal tumour surgery at this facility between January 2016, and December 2020. A total of one hundred twenty-seven participants in this experiment were included. The cervical area (46.02%), thoracic (30.1%), and lumbar (22.4%) spines had the greatest tumour incidence rates. When they were first diagnosed, the majority of patients (92.1%) had primary spinal tumours; however, some (08.07%) had metastatic tumours. Schwannoma was the most prevalent malignancy, with a frequency of 32.2%, followed by meningioma at 26.4% and metastatic cancers at 15.4%. The overall complication rate was 10.02%. Surprisingly, 98% of patients reported improved neurological function after surgery. According to the findings, it is fairly safe and beneficial for enhancing neurological development to remove spinal tumours.

    Spinal tumours; clinical spectrum' Surgical outcomes
    (1) Sajid Khan
    Assistant professor, Prime teaching hospital, Peshawar, KP, Pakistan.
    (2) Arif Hussain
    Senior registrar, Prime Hospital Peshawar, KP, Pakistan.
    (3) Muhammad Zubair
    Senior registrar, Prime Hospital Peshawar, KP, Pakistan.
    (4) Tariq Jamal
    Medical officer, Prime Hospital Peshawar, KP, Pakistan.
    (5) Mumtaz Ali
    Professor and HOD, Prime hospital Peshawar, KP, Pakistan.
  • Beall, D. P., Googe, D. J., Emery, R. E., Thompson, D. B., Campbell, S. E., Ly, J. Q., DeLone, D. R., Smirniotopoulos, J. G., Lisanti, C., & Currie, T. J. (2007). Extramedullary Intradural Spinal Tumors: A Pictorial Review. Current Problems in Diagnostic Radiology, 36(5), 185–198. https://doi.org/10.1067/j.cpradiol.2006.12.002
  • Conti, P., Pansini, G., Mouchaty, H., Capuano, C., & Conti, R. (2004). Spinal neurinomas: retrospective analysis and long-term outcome of 179 consecutively operated cases and review of the literature. Surgical Neurology, 61(1), 34–43. https://doi.org/10.1016/s0090-3019(03)00537-8
  • Engelhard, H. H., Villano, J. L., Porter, K. K., Stewart, A. K., Barua, M., Barker, F. G., & Newton, H. B. (2010). Clinical presentation, histology, and treatment in 430 patients with primary tumours of the spinal cord, spinal meninges, or cauda equina. Journal of Neurosurgery, 13(1), 67–77. https://doi.org/10.3171/2010.3.spine09430
  • Govind, M., Radheyshyam, M., Achal, S., & Ashok, G. (2016). Intradural extramedullary spinal cord tumours: a retrospective study at the tertiary referral hospital. Romanian Neurosurgery, 106- 112. https://journals.lapub.co.uk/index.php/roneurosurgery/article/view/882
  • Haq, N., Ali, M., Hussain, R., & Khan, H. (2015). Spectrum of intramedullary spinal cord tumours: Case series of 30 patients. ResearchGate. https://www.researchgate.net/publication/331700263_Spectrum_of_intramedullary_spinal_cord_tumours_Case_series_of_30_patients
  • Hersh, A., Patel, J., Pennington, Z., Porras, J. L., Goldsborough, E., Antar, A., Elsamadicy, A. A., Lubelski, D., Wolinsky, J. P., Jallo, G. I., Gokaslan, Z. L., Lo, S. F. L., & Sciubba, D. M. (2022). Perioperative outcomes and survival after surgery for intramedullary spinal cord tumours: a single-institution series of 302 patients. Journal of Neurosurgery, 37(2), 252– 262. https://doi.org/10.3171/2022.1.spine211235
  • Hirabayashi, H., Ebara, S., Kinoshita, T., Yuzawa, Y., Nakamura, I., Takahashi, J., Kamimura, M., Ohtsuka, K., & Takaoka, K. (2003). Clinical outcome and survival after palliative surgery for spinal metastases. Cancer, 97(2), 476–484. https://doi.org/10.1002/cncr.11039
  • Hufana, V., Tan, J., & Tan, K. (2005). Microsurgical treatment for spinal tumours. Singapore Medical Journal, 46(2), 74. http://www.smj.org.sg/sites/default/files/4602/4602a3.pdf
  • Ishida, W., Casaos, J., Chandra, A., D’Sa, A. A., Ramhmdani, S., Perdomo-Pantoja, A., Theodore, N., Jallo, G. I., Gokaslan, Z. L., Wolinsky, J. P., Sciubba, D. M., Bydon, A., Witham, T. F., & Lo, S. F. L. (2019). Diagnostic and therapeutic values of intraoperative electrophysiological neuromonitoring during resection of intradural extramedullary spinal tumours: a single-centre retrospective cohort and meta-analysis. Journal of Neurosurgery, 30(6), 839–849. https://doi.org/10.3171/2018.11.spine181095
  • Jørgensen, J. K., Ovesen, N. B., & Poulsen, J. A. (1976). Intraspinal Tumours in the First Two Decades of Life: Clinical and Radiological Features. Acta Orthopaedica Scandinavica. https://doi.org/10.3109/17453677608988707
  • Kozawa, E., Nishida, Y., Kawai, A., Hayakawa, K., Nokitaka, S., Kawashima, H., Iwata, S., Tsuchiya, H., Tsukushi, S., Takenaka, S., Imanishi, J., Baba, I., Nagano, A., Morii, T., Shirai, T., Shimizu, K., & Kawano, H. (2022). Clinical features and treatment outcomes of dedifferentiated and grade 3 chondrosarcoma: A multi-institutional study. Cancer Science, 113(7), 2397–2408. https://doi.org/10.1111/cas.15382
  • Lange, S., Probst, C., Gmel, G., Rehm, J., Burd, L., & Popova, S. (2017). Global Prevalence of Fetal Alcohol Spectrum Disorder Among Children and Youth. JAMA Pediatrics, 171(10), 948. https://doi.org/10.1001/jamapediatrics.2017.1919
  • McGrath, L. B., Kirnaz, S., Goldberg, J. L., Sommer, F., Medary, B., Hussain, I., & Härtl, R. (2022). Microsurgical Tubular Resection of Intradural Extramedullary Spinal Tumors With 3- Dimensional-Navigated Localization. Operative Neurosurgery, 23(4), e245–e255. https://doi.org/10.1227/ons.0000000000000365
  • Minehan, K. J., Brown, P. D., Scheithauer, B. W., Krauss, W. E., & Wright, M. E. (2009). Prognosis and Treatment of Spinal Cord Astrocytoma. International Journal of Radiation Oncology Biology Physics, 73(3), 727–733.
  • Mohammadi, E., Ghasemi, E., Azadnajafabad, S., Rezaei, N., Moghaddam, S. S., Meimand, S. E., Fattahi, N., Habibi, Z., Yarandi, K. K., Amirjamshidi, A., Nejat, F., Kompani, F.,
  • Mokdad, A. H., Larijani, B., & Farzadfar, F. (2021). A global, regional, and national survey on burden and Quality of Care Index (QCI) of the brain and other central nervous system cancers; global burden of disease systematic analysis 1990-2017. PLOS ONE, 16(2), e0247120. https://doi.org/10.1371/journal.pone.0247120
  • Ren, X., Wang, J., Hu, M., Jiang, H., Yang, J., & Jiang, Z. (2013). Clinical, radiological, and pathological features of 26 intracranial and intraspinal malignant peripheral nerve sheath tumours. Journal of Neurosurgery, 119(3), 695–708. https://doi.org/10.3171/2013.5.jns122119
  • Schick, U., Marquardt, G., & Lorenz, R. (2001). Intradural and extradural spinal metastases. Neurosurgical Review, 24(1), 1–5. https://doi.org/10.1007/pl00011959
  • Shah, S. N., Haq, N. U., Khan, M. I., Khan, Z., Shah, W., & Haq, M. I. U. (2023). Clinical Features and Surgical Outcomes of Spinal Tumors: A Multicenter Study. Pakistan Journal of Medical and Health Sciences, 17(2), 450–451. https://doi.org/10.53350/pjmhs2023172450
  • Takeda, S., Miyoshi, S., Akashi, A., Ohta, M., Minami, M., Okumura, M., Masaoka, A., & Matsuda, H. (2003). Clinical spectrum of primary mediastinal tumours: A comparison of adult and pediatric populations at a single Japanese institution. Journal of Surgical Oncology, 83(1), 24–30. https://doi.org/10.1002/jso.10231
  • Tilva, K. K., & Parikh, U. (2023). Histopathological Spectrum of Spinal Tumours at a Tertiary Care Hospital, Gujarat, India: A Retrospective Study. Journal of Clinical and Diagnostic Research. 7 https://doi.org/10.7860/jcdr/2023/59217.17277
  • Truong, V. T. T., Shedid, D., Al-Shakfa, F., Hattou, L., Shen, J., Boubez, G., Yuh, S., & Wang, Z. (2021). Surgical Intervention for Patients With Spinal Metastasis From Lung Cancer. Clinical Spine Surgery, 34(3), E133–E140. https://doi.org/10.1097/bsd.0000000000001062

Cite this article

    APA : Khan, S., Hussain, A., & Zubair, M. (2023). Spinal Tumors' Clinical Spectrum and Surgical Outcomes: Institutional Experience from a Single Center. Global Pharmaceutical Sciences Review, VIII(II), 6-11. https://doi.org/10.31703/gpsr.2023(VIII-II).02
    CHICAGO : Khan, Sajid, Arif Hussain, and Muhammad Zubair. 2023. "Spinal Tumors' Clinical Spectrum and Surgical Outcomes: Institutional Experience from a Single Center." Global Pharmaceutical Sciences Review, VIII (II): 6-11 doi: 10.31703/gpsr.2023(VIII-II).02
    HARVARD : KHAN, S., HUSSAIN, A. & ZUBAIR, M. 2023. Spinal Tumors' Clinical Spectrum and Surgical Outcomes: Institutional Experience from a Single Center. Global Pharmaceutical Sciences Review, VIII, 6-11.
    MHRA : Khan, Sajid, Arif Hussain, and Muhammad Zubair. 2023. "Spinal Tumors' Clinical Spectrum and Surgical Outcomes: Institutional Experience from a Single Center." Global Pharmaceutical Sciences Review, VIII: 6-11
    MLA : Khan, Sajid, Arif Hussain, and Muhammad Zubair. "Spinal Tumors' Clinical Spectrum and Surgical Outcomes: Institutional Experience from a Single Center." Global Pharmaceutical Sciences Review, VIII.II (2023): 6-11 Print.
    OXFORD : Khan, Sajid, Hussain, Arif, and Zubair, Muhammad (2023), "Spinal Tumors' Clinical Spectrum and Surgical Outcomes: Institutional Experience from a Single Center", Global Pharmaceutical Sciences Review, VIII (II), 6-11
    TURABIAN : Khan, Sajid, Arif Hussain, and Muhammad Zubair. "Spinal Tumors' Clinical Spectrum and Surgical Outcomes: Institutional Experience from a Single Center." Global Pharmaceutical Sciences Review VIII, no. II (2023): 6-11. https://doi.org/10.31703/gpsr.2023(VIII-II).02