http://dx.doi.org/10.31703/gpsr.2018(III-I).04
10.31703/gpsr.2018(III-I).04
Published : Dec 2018
An Overview of Factors Affecting Renal Clearance
Biological Renal clearance comprises multiple active and passive mechanisms, in turn leading to the formation of urine. In this article, a brief review of passive filtration in glomerular capillaries, active tubular secretion, and reabsorption is discussed. Factors affecting renal clearance have also been brought into the discussion, encompassing drug physicochemical properties, drug concentration, the volume of distribution, protein binding, blood flow to kidneys, biological factors, and drug interactions. Further, the necessity of dose adjustment in patients suffering renal impairment has been highlighted.
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Renal Clearance, Elimination, Excretion, Kidneys, Drugs
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(1) Mohammad Faizan Asif
Department of Pharmacy, Faculty of Biological Sciences, Quaid I Azam University, Islamabad, Pakistan.
(2) Shabana Gulzar Toor
Department of Pharmacy, Faculty of Biological Sciences, Quaid I Azam University, Islamabad, Pakistan.
(3) Fahad Pervaiz
Associate professor, Department of Pharmaceutics, Faculty of Pharmacy, Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan.
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Cite this article
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APA : Asif, M. F., Toor, S. G., & Pervaiz, F. (2018). An Overview of Factors Affecting Renal Clearance. Global Pharmaceutical Sciences Review, III(I), 27-31. https://doi.org/10.31703/gpsr.2018(III-I).04
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CHICAGO : Asif, Mohammad Faizan, Shabana Gulzar Toor, and Fahad Pervaiz. 2018. "An Overview of Factors Affecting Renal Clearance." Global Pharmaceutical Sciences Review, III (I): 27-31 doi: 10.31703/gpsr.2018(III-I).04
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HARVARD : ASIF, M. F., TOOR, S. G. & PERVAIZ, F. 2018. An Overview of Factors Affecting Renal Clearance. Global Pharmaceutical Sciences Review, III, 27-31.
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MHRA : Asif, Mohammad Faizan, Shabana Gulzar Toor, and Fahad Pervaiz. 2018. "An Overview of Factors Affecting Renal Clearance." Global Pharmaceutical Sciences Review, III: 27-31
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MLA : Asif, Mohammad Faizan, Shabana Gulzar Toor, and Fahad Pervaiz. "An Overview of Factors Affecting Renal Clearance." Global Pharmaceutical Sciences Review, III.I (2018): 27-31 Print.
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OXFORD : Asif, Mohammad Faizan, Toor, Shabana Gulzar, and Pervaiz, Fahad (2018), "An Overview of Factors Affecting Renal Clearance", Global Pharmaceutical Sciences Review, III (I), 27-31
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TURABIAN : Asif, Mohammad Faizan, Shabana Gulzar Toor, and Fahad Pervaiz. "An Overview of Factors Affecting Renal Clearance." Global Pharmaceutical Sciences Review III, no. I (2018): 27-31. https://doi.org/10.31703/gpsr.2018(III-I).04