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AN UPDATED REVIEW ON BIOLOGICAL HALFLIFE VOLUME OF DISTRIBUTION

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03 Pages : 19-26

http://dx.doi.org/10.31703/gpsr.2018(III-I).03      10.31703/gpsr.2018(III-I).03      Published : Dec 2018

An Updated Review on Biological Half-Life & Volume of Distribution

Abstract

    Biological half-life and volume of distribution of the drug are the key parameters in understanding the pharmacokinetics of the drugs within the body as they affect all the pharmacokinetic processes including absorption, distribution, metabolism and elimination of drugs and also associated with each other, ultimately effecting the Pharmacological action of the drug on its target site. Given study elaborates the various aspects of half-life, i.e., Alpha & beta half-lives, the contribution of Zero-order and first-order kinetics in ADME and interrelation among the volume of distribution & half-life along with the distribution & redistribution of the drug within the body. Moreover, the importance of half-life & Vd and the idea of Steady-state concentration is also discussed. Various types of physiological barriers, including the blood-brain barrier, placental barrier, blood-CSF barrier, affect the distribution of drugs.

    Half-Life, Clearance, Volume, Distribution, Binding

    (1) Rana Muhammad Awais Khan
    Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
    (2) Umair-ul-Hassan
    Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
    (3) Shafiq-ur-Rehman
    Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.
    (4) Nayab Tahir
    Lecturer, College of Pharmacy, University of Sargodha, Sargodha, Punjab, Pakistan.
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Cite this article

APA

    APA : Khan, R. M. A., Umair-ul-Hassan., & Shafiq-ur-Rehman. (2018). An Updated Review on Biological Half-Life & Volume of Distribution. Global Pharmaceutical Sciences Review, III(I), 19-26. https://doi.org/10.31703/gpsr.2018(III-I).03

CHICAGO

    CHICAGO : Khan, Rana Muhammad Awais, Umair-ul-Hassan, and Shafiq-ur-Rehman. 2018. "An Updated Review on Biological Half-Life & Volume of Distribution." Global Pharmaceutical Sciences Review, III (I): 19-26 doi: 10.31703/gpsr.2018(III-I).03

HARVARD

    HARVARD : KHAN, R. M. A., UMAIR-UL-HASSAN. & SHAFIQ-UR-REHMAN. 2018. An Updated Review on Biological Half-Life & Volume of Distribution. Global Pharmaceutical Sciences Review, III, 19-26.

MHRA

    MHRA : Khan, Rana Muhammad Awais, Umair-ul-Hassan, and Shafiq-ur-Rehman. 2018. "An Updated Review on Biological Half-Life & Volume of Distribution." Global Pharmaceutical Sciences Review, III: 19-26

MLA

    MLA : Khan, Rana Muhammad Awais, Umair-ul-Hassan, and Shafiq-ur-Rehman. "An Updated Review on Biological Half-Life & Volume of Distribution." Global Pharmaceutical Sciences Review, III.I (2018): 19-26 Print.

OXFORD

    OXFORD : Khan, Rana Muhammad Awais, Umair-ul-Hassan, , and Shafiq-ur-Rehman, (2018), "An Updated Review on Biological Half-Life & Volume of Distribution", Global Pharmaceutical Sciences Review, III (I), 19-26

TURABIAN

    TURABIAN : Khan, Rana Muhammad Awais, Umair-ul-Hassan, and Shafiq-ur-Rehman. "An Updated Review on Biological Half-Life & Volume of Distribution." Global Pharmaceutical Sciences Review III, no. I (2018): 19-26. https://doi.org/10.31703/gpsr.2018(III-I).03