Cyclodextrin Inclusion Complexes: Novel Techniques to Improve Solubility of Poorly Soluble Drugs: A Review
For a formulation scientist, the dilemma of solubility is a crucial test during the product development phase that can be resolved by opting various technological strategies. Some of the strategies that are usually applied for enhancing solubility of drugs with low aqueous solubility include micronization, solvent deposition and solid dispersion. With these approaches, some advantages as well as drawbacks, are affiliated. The strategy of complexation amid all techniques, has been applied more accurately for the improvement of dissolution profile, aqueous solubility, and bioavailability of poorly soluble drug candidates. Cyclodextrin are unique cyclic carbohydrates that have been exploited as successful complexing agents having capability of forming inclusion complexes with insoluble drugs. Numerous strategies have been considered to analyze the methods for preparation of inclusion complexes. In this review, we have pursued the discussion on different complexation techniques and in a nutshell, emphasized the applications and economical/technical limitations related to these techniques.
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Cyclodextrins, solubility, Inclusion Complexes, Bioavailability
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(1) Sobia Noreen
Faculty of Pharmacy & Alternative medicine, The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan.
(2) Irsah Maqbool
Faculty of Pharmacy & Alternative medicine, The Islamia University of Bahawalpur, Bahawalpur, Punjab, Pakistan.
(3) Muhammad Ijaz
Institute of Pharmaceutical Technology, University of Innsbruck, Austria.
(4) Sairah Tanveer
Dow College of Pharmacy (DUHS), Karachi, Sindh, Pakistan
- Cao, F., et al. (2005).
- Cavallari, C., et al. (2002).
- Chowdary, K. P. R., & Nalluri, B. N. (2000).
- Del Valle, E. M. M. (2004).
- El-Barghouthi, M. I. et al. (2006).
- Ghorab, M. K., & Adeyeye, M. C. (2001).
- Kanaka Durga Devi, N. et al. (2010). Cyclodextrins in pharmacy - An overview.
- Pandit, V. et al. (2011).
- Patil, S., & Jagadevappa. (2010). Inclusion complex system; a novel technique to improve the solubility and bioavailability of poorly soluble drugs: A review.
- Rawat, S., & Jain, S. K. (2004).
- Sanghavi, N. M. et al. (1993).
- Savjani, K. T., et al. (2012).
- Wen, X. et al. (2004).
Cite this article
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APA : Noreen, S., Maqbool, I., & Ijaz, M. (2016). Cyclodextrin Inclusion Complexes: Novel Techniques to Improve Solubility of Poorly Soluble Drugs: A Review. Global Pharmaceutical Sciences Review, I(I), 29-34. https://doi.org/10.31703/gpsr.2016(I-I).04
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CHICAGO : Noreen, Sobia, Irsah Maqbool, and Muhammad Ijaz. 2016. "Cyclodextrin Inclusion Complexes: Novel Techniques to Improve Solubility of Poorly Soluble Drugs: A Review." Global Pharmaceutical Sciences Review, I (I): 29-34 doi: 10.31703/gpsr.2016(I-I).04
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HARVARD : NOREEN, S., MAQBOOL, I. & IJAZ, M. 2016. Cyclodextrin Inclusion Complexes: Novel Techniques to Improve Solubility of Poorly Soluble Drugs: A Review. Global Pharmaceutical Sciences Review, I, 29-34.
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MHRA : Noreen, Sobia, Irsah Maqbool, and Muhammad Ijaz. 2016. "Cyclodextrin Inclusion Complexes: Novel Techniques to Improve Solubility of Poorly Soluble Drugs: A Review." Global Pharmaceutical Sciences Review, I: 29-34
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MLA : Noreen, Sobia, Irsah Maqbool, and Muhammad Ijaz. "Cyclodextrin Inclusion Complexes: Novel Techniques to Improve Solubility of Poorly Soluble Drugs: A Review." Global Pharmaceutical Sciences Review, I.I (2016): 29-34 Print.
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OXFORD : Noreen, Sobia, Maqbool, Irsah, and Ijaz, Muhammad (2016), "Cyclodextrin Inclusion Complexes: Novel Techniques to Improve Solubility of Poorly Soluble Drugs: A Review", Global Pharmaceutical Sciences Review, I (I), 29-34
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TURABIAN : Noreen, Sobia, Irsah Maqbool, and Muhammad Ijaz. "Cyclodextrin Inclusion Complexes: Novel Techniques to Improve Solubility of Poorly Soluble Drugs: A Review." Global Pharmaceutical Sciences Review I, no. I (2016): 29-34. https://doi.org/10.31703/gpsr.2016(I-I).04