To assess the knowledge of patient regarding the use of medications and to evaluate patient compliance, and the study was conducted in Chaudhary Pervaiz Elahi Institute of Cardiology, Multan, Pakistan. According to analysis, 81% of patients were from urban areas, and 19% of patients were from rural areas. 30% of them were literate, and 70% were illiterate. Most of the patients belonged to the age group of 40-50yars (71%). The majority of the affected persons were male, i.e.70%. The most commonly observed disease were IHD and hypertension, i.e.26% and 24.5%, respectively. 36% of the patients had a history of CVS disorders in their families. The influence of lifestyle was analyzed with regard to smoking, drinking and lack of physical activities. There is a need for educational strategies for the patient to recognize the significance of compliance for this disease. Also, educational intervention is required for prescriber and hospital pharmacist to improve prescribing and dispensing.