http://dx.doi.org/10.31703/gpsr.2023(VIII-II).05
10.31703/gpsr.2023(VIII-II).05
Published : Jun 2023
Estimation of Serum Zinc and Copper in Children with Acute Diarrhea
Diarrhoea is a disease related to nutrition as it involves the loss of fluid and electrolytes. The death rate in children due to diarrhoea is high because of undernutrition, even if they are well-hydrated. In this examination, we sought out the concentrations of copper and zinc in the serum of children diseased with acute diarrhoea, before and after the therapy of standard ORS (oral rehydration solution) therapy and associated it with the severity of diarrhoea and its period. Children involved in the examination were 110 in number, who were diseased with acute diarrhoea. The concentrations of zinc and copper in the serum of children with acute diarrhoea were noted before (at the time of entrance) and after treating them with standard oral rehydration solution (ORS) therapy. This research showed that the levels of zinc and copper in the serum of children diseased with acute diarrhoea, declined significantly to 13% and 12.8%, respectively, from their normal serum concentrations. After treatment with ORS therapy, a further decrease of 22.4% and 22.6% is seen in the concentration of zinc and copper, respectively. Our research showed that the children who were having a very low level of zinc and copper in the plasma were more prone to be diseased with acute diarrhoea and even more severely and with longer duration.
-
Serum Zinc, Copper, Children, Acute Diarrhoea, ORS Therapy
-
(1) Bela Inayat
Senior Lecturer, Department of Biochemistry, Khyber Girls Medical College, Peshawar, KP, Pakistan.
(2) Mehreen Ismail
Department of Biochemistry, Khyber Medical University, Peshawar, KP, Pakistan.
(3) Aziz Ur Rehman
Associate Professor, Department of Biochemistry, Rehman Medical College, Peshawar, KP, Pakistan.
(4) Tehreem Shahid
Lecturer, Department of Physiology, Rehman Medical and Dental College, Peshawar, KP, Pakistan.
(5) Javaid Hassan
Assistant Professor, Department of Physiology, Muhammad College of Medicine, Peshawar, KP, Pakistan.
(6) Farid Ullah Shah
Associate Professor, Department of Biochemistry, Pak International Medical College, Peshawar, KP, Pakistan.
- Barffour, M. A., Matta, J., Wessells, K. R., Kounnavong, S., Ratsavong, K., Sitthideth, D., Bounheuang, B., Sengnam, K., Chanhthavong, B., Arnold, C. D., Brown, K. H., Larson, C. R., & Hess, S. (2020). Effects of therapeutic zinc supplementation for diarrhea and two preventive zinc supplementation regimens on the incidence and duration of diarrhea and acute respiratory tract infections in rural Laotian children: A randomized controlled trial. Journal of Global Health, 10(1). https://doi.org/10.7189/jogh.10.010424
- Bazer, F. W. (2009b). Amino acids: metabolism, functions, and nutrition. Amino Acids, 37(1), 1– 17. https://doi.org/10.1007/s00726-009-0269-0
- Bhowmik, D., Chiranjib, K., & Kumar, S. (2010). Potential medicinal importance of zinc in human health and chronic. Int J Pharm Biomed Sci 2010, 1(1), 05-11 https://www.researchgate.net/publication/277014212_A_potential_medicinal_importance_of_zinc_in_human_health_and_chronic_disease
- Bwanaisa, L., Heyderman, R. S., & Molyneux, E. (2011). The challenges of managing severe dehydrating diarrhoea in a resource-limited setting. International Health, 3(3), 147–153. https://doi.org/10.1016/j.inhe.2011.03.007
- Gillespie, S., & Haddad, L. (2001). Attacking the double burden of malnutrition in Asia and the Pacific. Asian Development Bank. https://think- asia.org/handle/11540/274
- Grote, V., & Koletzko, B. (2016). Breastfeeding and Complementary Feeding. Deutsches Arzteblatt International. https://doi.org/10.3238/arztebl.2016.0435
- Halliez, M. C. M., & Buret, A. G. (2013). Extra- intestinal and long term consequences of Giardia duodenalis infections. World Journal of Gastroenterology, 19(47), 8974. https://doi.org/10.3748/wjg.v19.i47.8974
- Josephy, P. D., & Mannervik, B. (2006). Molecular toxicology. Oxford University Press
- Larson, C. R., Roy, S., Khan, A. I., Rahman, A. S., & Qadri, F. (2009). Zinc Treatment to Under-five Children: Applications to Improve Child Survival and Reduce Burden of Disease. Journal of Health Population and Nutrition, 26(3). https://doi.org/10.3329/jhpn.v26i3.1901
- Mehta, N. M., Corkins, M. R., Lyman, B., Malone, A., Goday, P. S., Carney, L. N., Monczka, J., Plogsted, S. W., & Schwenk, W. F. (2013). Defining Pediatric Malnutrition. Journal of Parenteral and Enteral Nutrition, 37(4), 460– 481. https://doi.org/10.1177/0148607113479972
- Prasad, A. S. (2009). Impact of the Discovery of Human Zinc Deficiency on Health. Journal of the American College of Nutrition, 28(3), 257–265. https://doi.org/10.1080/07315724.2009.10719780
- Scrimshaw, N. B. (1968). Interactions of Nutrition and Infection. World Health Organization
- Wapnir, R. A. (1998). Copper absorption and bioavailability. The American Journal of Clinical Nutrition, 67(5), 1054S-1060S. https://doi.org/10.1093/ajcn/67.5.1054s
- Wilson, S., Morris, S. S., Gilbert, S. C., Mosites, E., Hackleman, R., Weum, K. L., Pintye, J., Manhart, L. E., & Hawes, S. E. (2013). Scaling up access to oral rehydration solution for diarrhea: Learning from historical experience in low– and high– performing countries. Journal of Global Health, 3(1). https://doi.org/10.7189/jogh.03.010404
Cite this article
-
APA : Inayat, B., Ismail, M., & Rehman, A. U. (2023). Estimation of Serum Zinc and Copper in Children with Acute Diarrhea. Global Pharmaceutical Sciences Review, VIII(II), 23-26. https://doi.org/10.31703/gpsr.2023(VIII-II).05
-
CHICAGO : Inayat, Bela, Mehreen Ismail, and Aziz Ur Rehman. 2023. "Estimation of Serum Zinc and Copper in Children with Acute Diarrhea." Global Pharmaceutical Sciences Review, VIII (II): 23-26 doi: 10.31703/gpsr.2023(VIII-II).05
-
HARVARD : INAYAT, B., ISMAIL, M. & REHMAN, A. U. 2023. Estimation of Serum Zinc and Copper in Children with Acute Diarrhea. Global Pharmaceutical Sciences Review, VIII, 23-26.
-
MHRA : Inayat, Bela, Mehreen Ismail, and Aziz Ur Rehman. 2023. "Estimation of Serum Zinc and Copper in Children with Acute Diarrhea." Global Pharmaceutical Sciences Review, VIII: 23-26
-
MLA : Inayat, Bela, Mehreen Ismail, and Aziz Ur Rehman. "Estimation of Serum Zinc and Copper in Children with Acute Diarrhea." Global Pharmaceutical Sciences Review, VIII.II (2023): 23-26 Print.
-
OXFORD : Inayat, Bela, Ismail, Mehreen, and Rehman, Aziz Ur (2023), "Estimation of Serum Zinc and Copper in Children with Acute Diarrhea", Global Pharmaceutical Sciences Review, VIII (II), 23-26
-
TURABIAN : Inayat, Bela, Mehreen Ismail, and Aziz Ur Rehman. "Estimation of Serum Zinc and Copper in Children with Acute Diarrhea." Global Pharmaceutical Sciences Review VIII, no. II (2023): 23-26. https://doi.org/10.31703/gpsr.2023(VIII-II).05