The oral mucosa offers an attractive route for the systemic delivery of drugs. The bioavailability and effectiveness of many drugs can be increased by administering them through the oral mucosa which bypasses the first-pass metabolism effect. This article will discuss principles, application areas, benefits & drawbacks as well as possible future perspectives for the study and development of oromucosal drug delivery systems. Among the critical benefits of administering drugs via the mouth is that it starts acting fast, is easily absorbed into the bloodstream, makes it easier for patients to follow their prescriptions as well and offers more freedom in terms of dosage control. The article emphasizes innovative technologies such as nanoparticulate formulations as well as microfabricated devices which are slated to improve drug targeting and delivery. It also touches on such related issues as taste masking, variability in bioavailability, and regulatory concerns.