This review article investigates how Quality by Design (QbD) ideas are used in different pharmaceutical development processes, such as the creation of analytical methods, formulation optimization, and nanoparticle production. In order to improve product quality, reliability, and regulatory compliance, it covers a variety of studies that use QbD approaches. Critical quality attributes and process variables are discovered and optimized to meet desired product characteristics through systematic methodologies such as central composite design, factorial design, and response surface analysis. The experiments demonstrate the adaptability and effectiveness of the QbD strategy in pharmaceutical development by examining a range of drug delivery systems, including lipid nanoparticles and fast dissolving tablets. The significance of QbD is emphasized in the article as a means of guaranteeing uniform product quality, fulfilling regulatory obligations, and enhancing patient outcomes.