ARTICLE

SKIN BURNS PATHOPHYSIOLOGY TYPES AND THERAPEUTIC APPROACHES

01 Pages : 1-6

http://dx.doi.org/10.31703/gpsr.2018(III-I).01      10.31703/gpsr.2018(III-I).01      Published : Dec 2018

Skin Burns: pathophysiology, types and Therapeutic Approaches

    Burn injury is considered as one of the complex traumatic events affecting multiple organs with local and systemic side effects. Burn trauma may be represented as a type of injury by heat, electricity, chemical, radiation, freezing, and friction. However, profound nerve injury may damage the muscle, bone, vascular, dermal, and epidermal tissues. Burns victims may experience many potentially fatal complications depending upon the location affected and the depth of burns, such as burn shock, electrolyte imbalance, and respiratory failure. This article reviews the pathophysiology, types, and recent advancements with a focus on the therapeutic approaches

    Burn Injury, Burn Trauma, Pathophysiology, Recent Advancements
    (1) Sobia Noreen
    Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Punjab, Pakistan.
    (2) Irsah Maqbool
    Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Punjab, Pakistan.
    (3) Saba Ijaz
    Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Punjab, Pakistan.
  • Cope, O., & Moore, F. D. (1947). The redistribution of body water and the fluid therapy of the burned patient. Annals of surgery, 126(6), 1010.
  • Dries, D. J. (2009). Management of burn injuries-recent developments in resuscitation, infection control and outcomes research. Scandinavian journal of trauma, resuscitation and emergency medicine, 17(1), 14.
  • Edgar, D. W., Fish, J. S., Gomez, M., & Wood, F. M. (2011). Local and systemic treatments for acute edema after burn injury: a systematic review of the literature. Journal of burn care & research, 32(2), 334-347.
  • Evers, L. H., Bhavsar, D., & Mailänder, P. (2010). The biology of burn injury. Experimental dermatology, 19(9), 777-783.
  • Farina, J. A., Rosique, M. J., & Rosique, R. G. (2013). Curbing inflammation in burn patients. International journal of inflammation, 2013.
  • Farina Junior, J. A., Rosique, M. J. F., & Rosique, R. G. (2013). Curbing inflammation in burn patients.
  • Feck, G., Baptiste, M. S., & Tate Jr, C. L. (1979). Burn injuries: epidemiology and prevention. Accident Analysis & Prevention, 11(2), 129-136.
  • Forjuoh, S. N. (2006). Burns in low-and middle-income countries: a review of available literature on descriptive epidemiology, risk factors, treatment, and prevention. Burns, 32(5), 529- 537.
  • Gibran, N. S., Wiechman, S., Meyer, W., Edelman, L., Fauerbach, J., Gibbons, L., . . . Kirk, E. (2013). American burn association consensus statements: ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX.
  • Granger, J., Estrada, C., Abramo, T., Grant, V., & Tothy, A. (2009). An evidence-based approach to pediatric burns. Pediatric Emergency Medicine Practice, 6(1), 1-17.
  • Gurtner, G. C., Werner, S., Barrandon, Y., & Longaker, M. T. (2008). Wound repair and regeneration. Nature, 453(7193), 314.
  • Herndon, D. (2012). Evaluation of the burn wound: management desicions. Total burn care: Philadelphia: Saunders
  • Hettiaratchy, S., & Dziewulski, P. (2004). Pathophysiology and types of burns. Bmj, 328(7453), 1427-1429.
  • Keck, M., Herndon, D. H., Kamolz, L. P., Frey, M., & Jeschke, M. G. (2009). Pathophysiology of burns. Wiener Medizinische Wochenschrift, 159(13-14), 327-336.
  • Lloyd, E. C., Rodgers, B. C., Michener, M., & Williams, M. S. (2012). Outpatient burns: prevention and care. American family physician, 85(1).
  • Mann, E. A., Wood, G. L., & Wade, C. E. (2011). Use of procalcitonin for the detection of sepsis in the critically ill burn patient: a systematic review of the literature. Burns, 37(4), 549-558.
  • Mann, R., & Heimbach, D. (1996). Prognosis and treatment of burns. Western Journal of Medicine, 165(4), 215.
  • Norbury, W., Herndon, D. N., Tanksley, J., Jeschke, M. G., Finnerty, C. C., & Society, S. S. C. o. t. S. I. (2016). Infection in burns. Surgical infections, 17(2), 250-255.
  • Organization, W. H. (2008). A WHO plan for burn prevention and care.
  • Othman, N., & Kendrick, D. (2010). Epidemiology of burn injuries in the East Mediterranean Region: a systematic review. BMC public health, 10(1), 83.
  • Palao, R., Monge, I., Ruiz, M., & Barret, J. (2010). Chemical burns: pathophysiology and treatment. Burns, 36(3), 295-304.
  • Pastar, I., Stojadinovic, O., Yin, N. C., Ramirez, H., Nusbaum, A. G., Sawaya, A., . . . Tomic-Canic, M. (2014). Epithelialization in wound healing: a comprehensive review. Advances in wound care, 3(7), 445-464.
  • Peck, M. D. (2011). Epidemiology of burns throughout the world. Part I: Distribution and risk factors. Burns, 37(7), 1087-1100.
  • Pham, T. N., Cancio, L. C., & Gibran, N. S. (2008). American Burn Association practice guidelines burn shock resuscitation. Journal of burn care & research, 29(1), 257-266.
  • Porter, C., Hurren, N. M., Herndon, D. N., & Børsheim, E. (2013). Whole body and skeletal muscle protein turnover in recovery from burns. International journal of burns and trauma, 3(1), 9.
  • Rowan, M. P., Cancio, L. C., Elster, E. A., Burmeister, D. M., Rose, L. F., Natesan, S., . . . Chung, K. K. (2015). Burn wound healing and treatment: review and advancements. Critical care, 19(1), 243.
  • Sakallioglu, A. E., Basaran, O., Karakayali, H., Ozdemir, B. H., Yucel, M., Arat, Z., & Haberal, M. (2006). Interactions of systemic immune response and local wound healing in different burn depths: an experimental study on rats. Journal of burn care & research, 27(3), 357-366.
  • Sepsis, A. B. A. C. C. o. B., Group, I., Greenhalgh, D. G., Saffle, J. R., Holmes IV, J. H., Gamelli, R. L., . . . Mozingo, D. W. (2007). American Burn Association consensus conference to define sepsis and infection in burns. Journal of burn care & research, 28(6), 776-790.
  • Shih, B., Garside, E., McGrouther, D. A., & Bayat, A. (2010). Molecular dissection of abnormal wound healing processes resulting in keloid disease. Wound repair and regeneration, 18(2), 139-153.
  • Shirani, K. Z., Vaughan, G. M., Mason, J. A., & Pruitt, J. B. (1996). Update on current therapeutic approaches in burns. Shock (Augusta, Ga.), 5(1), 4-16.
  • Singer, A. J., & Clark, R. A. (1999). Cutaneous wound healing. New England journal of medicine, 341(10), 738-746.
  • Snowden, J. M. (1984). Wound closure: an analysis of the relative contributions of contraction and epithelialization. Journal of Surgical Research, 37(6), 453-463.
  • Sommer, K., Sander, A. L., Albig, M., Weber, R., Henrich, D., Frank, J., . . . Jakob, H. (2013). Delayed wound repair in sepsis is associated with reduced local pro-inflammatory cytokine expression. PLoS One, 8(9), e73992.
  • Tintinalli, J. E. (2010). Emergency medicine: A comprehensive study guide (emergency medicine (Tintinalli)). New YorN: McGraw-Hill Companies, 480.
  • Tiwari, V. (2012). Burn wound: How it differs from other wounds? Indian journal of plastic surgery, 45(02), 364-373.
  • Underhill, F. P., Carrington, G. L., Kapsinow, R., & Pack, G. T. (1923). Blood concentration changes in extensive superficial burns, and their significance for systemic treatment. Archives of Internal Medicine, 32(1), 31-49.
  • Werner, S., Krieg, T., & Smola, H. (2007). Keratinocyte- fibroblast interactions in wound healing. Journal of Investigative Dermatology, 127(5), 998- 1008.
  • Widgerow, A. D. (2011). Cellular/extracellular matrix cross-talk in scar evolution and control. Wound repair and regeneration, 19(2), 117-133.
  • Wilmore, D. W., Long, J. M., Mason Jr, A. D., Skreen, R. W., & Pruitt Jr, B. A. (1974). Catecholamines: mediator of the hypermetabolic response to thermal injury. Annals of surgery, 180(4), 653

Cite this article

    CHICAGO : Noreen, Sobia, Irsah Maqbool, and Saba Ijaz. 2018. "Skin Burns: pathophysiology, types and Therapeutic Approaches." Global Pharmaceutical Sciences Review, III (I): 1-6 doi: 10.31703/gpsr.2018(III-I).01
    HARVARD : NOREEN, S., MAQBOOL, I. & IJAZ, S. 2018. Skin Burns: pathophysiology, types and Therapeutic Approaches. Global Pharmaceutical Sciences Review, III, 1-6.
    MHRA : Noreen, Sobia, Irsah Maqbool, and Saba Ijaz. 2018. "Skin Burns: pathophysiology, types and Therapeutic Approaches." Global Pharmaceutical Sciences Review, III: 1-6
    MLA : Noreen, Sobia, Irsah Maqbool, and Saba Ijaz. "Skin Burns: pathophysiology, types and Therapeutic Approaches." Global Pharmaceutical Sciences Review, III.I (2018): 1-6 Print.
    OXFORD : Noreen, Sobia, Maqbool, Irsah, and Ijaz, Saba (2018), "Skin Burns: pathophysiology, types and Therapeutic Approaches", Global Pharmaceutical Sciences Review, III (I), 1-6
    TURABIAN : Noreen, Sobia, Irsah Maqbool, and Saba Ijaz. "Skin Burns: pathophysiology, types and Therapeutic Approaches." Global Pharmaceutical Sciences Review III, no. I (2018): 1-6. https://doi.org/10.31703/gpsr.2018(III-I).01