ARTICLE

FORMULATION AND INVITRO EVALUATION OF SUSTAINED RELEASE PILOCARPINE OCUSERTS USING MODIFIED KARAYA GUM EXTRACTED FROM STERCULIA URENS

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05 Pages : 28-40

http://dx.doi.org/10.31703/gpsr.2022(VII-I).05      10.31703/gpsr.2022(VII-I).05      Published : Dec 2022

Formulation and In-Vitro Evaluation of Sustained Release Pilocarpine Ocuserts Using Modified Karaya Gum Extracted from Sterculia urens

Abstract

    Ocular inserts of Pilocarpine nitrate (PN) were prepared using modified karaya gum (MKG) alone as release retarding polymer and in combination with the copolymer sodium alginate. Modification of the karaya gum was done by treating it with the trisodium trimetaphosphate (STMP) by cross linking method and evaluated for its physicochemical properties. Films of the MKG were prepared by employing solvent casting method using varying concentrations (600mg, 500mg and 400mg) of MKG and the sandwiching technique was used for the loading of drug. Sodium alginate (SA) and PN blend were prepared by triturating their appropriate amounts. Six ocusert formulations (F1-F6) were prepared with different concentrations of the polymer i.e MKG and SA while the amount of PN was kept constant in formulations. Formulations F1-F3 contained the MKG alone in varying concentrations (600mg, 500mg and 400mg) and F4-F6 contained SA (0.5 mg) in addition to MKG. The surface pH of prepared ocuserts from the formulations (F1-F6) was in the range of 6.63 to 6.8. Thickness range of the ocuserts was from 0.21 to 0.32 mm. Dissolution profiles of prepared ocuserts were studied and drug release was found within the range of 69.2± 1.36 % (F4, minimum) to 90.5± 3.21% (F3, maximum). Overall results of the study concluded that ocuserts fabricated with MKG and SA at optimized concentrations have the potential to sustain the release of PN and therefore reducing dosing frequency and adverse effects.

    Ocuserts, sodium alginate, crosslinking, solvent casting, diffusion

    (1) Sajida Shareef
    Riphah Institute of Pharmaceutical Sciences, Riphah International University, 54000, Lahore, Punjab, Pakistan.
    (2) Muhammad Imran Khan
    Riphah Institute of Pharmaceutical Sciences, Riphah International University, 54000, Lahore, Punjab, Pakistan.
    (3) Muhammad Farhan Sohail
    Riphah Institute of Pharmaceutical Sciences, Riphah International University, 54000, Lahore, Punjab, Pakistan.
    (4) Muhammad Furqan Akhtar
    Riphah Institute of Pharmaceutical Sciences, Riphah International University, 54000, Lahore, Punjab, Pakistan.
    (5) Athar Masood
    Riphah Institute of Pharmaceutical Sciences, Riphah International University, 54000, Lahore, Punjab, Pakistan.
    (6) Sufyan Junaid Usmani
    Riphah Institute of Pharmaceutical Sciences, Riphah International University, 54000, Lahore, Punjab, Pakistan.
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Cite this article

APA

    APA : Shareef, S., Khan, M. I., & Sohail, M. F. (2022). Formulation and In-Vitro Evaluation of Sustained Release Pilocarpine Ocuserts Using Modified Karaya Gum Extracted from Sterculia urens. Global Pharmaceutical Sciences Review, VII(I), 28-40. https://doi.org/10.31703/gpsr.2022(VII-I).05

CHICAGO

    CHICAGO : Shareef, Sajida, Muhammad Imran Khan, and Muhammad Farhan Sohail. 2022. "Formulation and In-Vitro Evaluation of Sustained Release Pilocarpine Ocuserts Using Modified Karaya Gum Extracted from Sterculia urens." Global Pharmaceutical Sciences Review, VII (I): 28-40 doi: 10.31703/gpsr.2022(VII-I).05

HARVARD

    HARVARD : SHAREEF, S., KHAN, M. I. & SOHAIL, M. F. 2022. Formulation and In-Vitro Evaluation of Sustained Release Pilocarpine Ocuserts Using Modified Karaya Gum Extracted from Sterculia urens. Global Pharmaceutical Sciences Review, VII, 28-40.

MHRA

    MHRA : Shareef, Sajida, Muhammad Imran Khan, and Muhammad Farhan Sohail. 2022. "Formulation and In-Vitro Evaluation of Sustained Release Pilocarpine Ocuserts Using Modified Karaya Gum Extracted from Sterculia urens." Global Pharmaceutical Sciences Review, VII: 28-40

MLA

    MLA : Shareef, Sajida, Muhammad Imran Khan, and Muhammad Farhan Sohail. "Formulation and In-Vitro Evaluation of Sustained Release Pilocarpine Ocuserts Using Modified Karaya Gum Extracted from Sterculia urens." Global Pharmaceutical Sciences Review, VII.I (2022): 28-40 Print.

OXFORD

    OXFORD : Shareef, Sajida, Khan, Muhammad Imran, and Sohail, Muhammad Farhan (2022), "Formulation and In-Vitro Evaluation of Sustained Release Pilocarpine Ocuserts Using Modified Karaya Gum Extracted from Sterculia urens", Global Pharmaceutical Sciences Review, VII (I), 28-40

TURABIAN

    TURABIAN : Shareef, Sajida, Muhammad Imran Khan, and Muhammad Farhan Sohail. "Formulation and In-Vitro Evaluation of Sustained Release Pilocarpine Ocuserts Using Modified Karaya Gum Extracted from Sterculia urens." Global Pharmaceutical Sciences Review VII, no. I (2022): 28-40. https://doi.org/10.31703/gpsr.2022(VII-I).05